Central control of body temperature

Central control of body temperature

Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors fo...

Brain control of body temperature: Central command vs feedback

In his landmark Physiological Reviews article of 1929 Walter Cannon defined homeostasis as the coordinated physiological mechanisms that maintain the physical and chemical properties of the internal environment, i.e. the extracellular fluid that surrounds all cells in the body. This in turn was based on the principle, first enunciated by Claude Bernard, that the constancy of the internal enviro...

Warm-Sensitive Neurons that Control Body Temperature

Thermoregulation is one of the most vital functions of the brain, but how temperature information is converted into homeostatic responses remains unknown. Here, we use an unbiased approach for activity-dependent RNA sequencing to identify warm-sensitive neurons (WSNs) within the preoptic hypothalamus that orchestrate the homeostatic response to heat. We show that these WSNs are molecularly defi...

Nitric Oxide and Body Temperature Control.

Pharmacological studies of thermoregulatory effector and neuronal responses indicate that nitric oxide (NO) may have differential roles in the control of body temperature and during fever. Histochemical analysis of site-specific changes in NO synthase activity in defined states of thermal stimulation appears a promising approach to unravel the underlying hypothalamic neuronal cytoarchitecture.

Kazuhiro Nakamura fever Central circuitries for body temperature regulation and